Hormonal
Endurance exercise training increases the proportion of slow-twitch (ST) fibers and oxidative capacity, which protects against insulin resistance and obesity.
Incorporate regular endurance exercise into your routine. This type of training triggers molecular changes (increasing PGC-1 and PPAR-α) that shift your muscle toward a more metabolically efficient, insulin-sensitive state, helping to prevent obesity and type 2 diabetes.
skeletal muscle remodeling to a ST phenotype, either through activated calcineurin or PPARδ, can protect against the development of dietary-induced insulin resistance (Ryder et al. 2003) and obesity (Wang et al. 2004).
Why this rating
Cites functional genomics studies in mice (Wang 2004, Ryder 2003) and human studies (Russell 2003) showing fiber-type specific increases in key proteins.
Source
Skeletal muscle fibre type: Influence on contractile and metabolic properties
Juleen R. Zierath et al. · RMIT Research Repository (RMIT University Library) · 2004
DOI 10.1371/journal.pbio.0020348
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