Research
Hormonal
Tirzepatide, a GLP-1/GIP receptor co-agonist, produces superior weight loss and glycemic control compared to selective GLP-1 receptor agonists and insulin in patients with type 2 diabetes.
If you have type 2 diabetes, tirzepatide is a once-weekly injection that lowers blood sugar and helps you lose more weight than older diabetes medications. It is generally well-tolerated, though you may experience gastrointestinal side effects. Discuss with your doctor if this once-weekly option is right for you.
GoodSupportsHIGH confidence
In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo... and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48].
Why this rating
Based on multiple phase 3 randomized controlled trials (SURPASS, SURMOUNT) cited in the review.
Source
GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes
Stefano Ciardullo et al. · Acta Diabetologica · 2024
DOI 10.1007/s00592-024-02300-6
narrative_reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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