Hormonal
Poor glycemic control exacerbates dyslipidemia in diabetes by increasing hepatic VLDL production and decreasing HDL levels, while improvements in glycemic control can reverse these lipid abnormalities.
For people with diabetes, keeping blood sugar levels in range is important, but it is not enough to protect your heart. Even if your A1C is good, you likely still have abnormal cholesterol levels, specifically high triglycerides and low HDL. This is because diabetes changes how your liver processes fats. You need to monitor your lipid profile separately and likely take medication (like statins) to manage cardiovascular risk, regardless of how well your blood sugar is controlled.
In both Type 1 and Type 2 diabetes, poor glycemic control increases serum triglyceride levels, VLDL and IDL, and decreases HDL... Improvements in glycemic control can markedly lower serum triglyceride levels and may increase serum HDL levels.
Why this rating
Based on consistent mechanistic explanations and observational data across multiple studies cited in the review.
Source
The significance of ratio between serum triglycerides and HDL cholesterol as a common man’s bio marker of insulin resistance in type 2 diabetes mellitus: A cross sectional comparative study
Krishnamurthy HA et al. · Journal of Medical and Scientific Research · 2023
DOI 10.17727/jmsr.2023/11-39
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