Hormonal
In patients with Type 2 Diabetes and a CAC score of 0 (very low risk), de-escalating multifactorial treatment targets (e.g., less intensive lipid and blood pressure management) is non-inferior to standard treatment regarding cardiovascular events.
If you have Type 2 Diabetes but a Coronary Artery Calcification (CAC) score of 0, your risk of a cardiovascular event is very low (about 1% over 5 years). This trial investigates whether it is safe to reduce the intensity of your cholesterol and blood pressure medications compared to standard care. If your CAC is 0, you might be able to simplify your medication regimen with your doctor, focusing on glucose control and avoiding side effects, without significantly increasing your heart risk.
We hypothesise that downgraded multifactorial treatment is non- inferior to standard treatment in patients with CAC score of zero.
Why this rating
This is a study protocol; results are pending.
Source
Study protocol for the investigator-initiated Danish pragmatic randomised STENO INTEN-CT trial: does screening and intervention for subclinical coronary artery disease in type 2 diabetes reduce cardiovascular events?
Kristian Løkke Funck et al. · BMJ Open · 2025
DOI 10.1136/bmjopen-2025-106018
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