Research
Hormonal
RCII partially mediates the association between ABSI and incident CVD, with the mediation proportion increasing across higher ABSI quartiles.
Understanding that inflammation and lipid metabolism (RCII) play a role in how abdominal fat (ABSI) affects heart health can guide more targeted treatments. For those with high ABSI, addressing inflammation may provide additional cardiovascular protection beyond just weight management.
GoodQualifiesHIGH confidence
The proportion of RCII’s mediating effects in the second, third, and fourth quartiles of ABSI was 5.00%, 12.84%, and 17.17%, respectively.
Why this rating
Mediation analysis performed on a large prospective cohort.
Source
The effects of a body shape index and remnant cholesterol inflammatory index on incident cardiovascular diseases: insights from a nationwide cohort study
Linghao Xu et al. · Lipids in Health and Disease · 2026
DOI 10.1186/s12944-026-02893-7
cohort · n=7780
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Elevated Remnant Cholesterol Inflammatory Index (RCII) is independently associated with a significantly higher risk of incident cardiovascular disease (CVD), including heart disease and stroke.Good
- A Body Shape Index (ABSI) is associated with incident cardiovascular disease, with the highest risk observed in individuals with high ABSI combined with high RCII.Good
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