Hormonal
Adding luseogliflozin (an SGLT2 inhibitor) to incretin modulator therapy produces an additive glucose-lowering effect, specifically reducing time above range, with the magnitude of benefit being significantly greater in patients consuming high-carbohydrate diets compared to low-carbohydrate diets.
If you are taking an incretin-based diabetes medication (like a GLP-1 agonist or DPP4 inhibitor) and consume a diet high in carbohydrates (e.g., >180g carbs daily), adding luseogliflozin (2.5mg daily) may provide better blood sugar control than adding it to a low-carb diet. This combination appears to work additively, meaning the drugs complement each other to handle the glucose load from carbs more effectively than either might alone in that specific context.
In this study, the observed number was small; however, combined treatment with an incretin modulator and luseogliflozin had an additive effect in high- versus low-carbohydrate intake, indicating the possible effectiveness of the combined therapy.
Why this rating
Small sample size (n=35), single-center, short duration (2 weeks), and lack of blinding reduce the strength of evidence.
Source
Luseogliflozin Additively Enhances the Glucose-Lowering Effect of an Incretin Modulator in a High-Carbohydrate Diet
Gendai Lee · Cureus · 2022
DOI 10.7759/cureus.30410
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