Hormonal
Carrying the G alleles of ALPK1 polymorphisms rs2074388 or rs2074379 significantly increases the susceptibility to developing type 2 diabetes mellitus in Japanese individuals.
If you are of Japanese descent, knowing you carry specific ALPK1 variants (rs2074388 or rs2074379) means you have a higher genetic risk for type 2 diabetes. This does not mean you will definitely get it, but it suggests you should be vigilant about maintaining a healthy weight, managing blood sugar, and limiting inflammatory foods to counteract this predisposition.
The multivariable logistic regression analysis with adjustment for age, gender, body mass index and smoking status revealed that the rs2074388 (P=0.0051; odds ratio, 1.32) and rs2074379 (P=0.0058; odds ratio, 1.32) variants were significantly associated with type 2 DM.
Why this rating
Large sample size (n=5,959) and population-based cohort design, but limited to a specific ethnic group (Japanese) and lacks functional validation of the specific variants.
Source
Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community-dwelling individuals
SHIGETAKA SHIMOKATA et al. · Biomedical Reports · 2013
DOI 10.3892/br.2013.173
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