Research
Hormonal
Semaglutide effectively reverses alectinib-induced excessive weight gain in ALK+ NSCLC patients, though discontinuation due to gallstone pancreatitis can lead to weight regain.
If you are on alectinib and gaining significant weight, semaglutide can help you lose it, but you must get a baseline gallbladder ultrasound first. If you develop abdominal pain, stop the drug immediately as it may cause pancreatitis, which will cause you to regain the weight you lost.
WeakQualifiesVERY_LOW confidence
she subsequently lost approximately 8 kg over a one-month period... within 2 to 3 months, she experienced additional weight loss of 6 kg, representing a 21.4% decrease in weight from her peak weight... she was seen at an outside institution for acute gallstone pancreatitis suspected to be triggered by semaglutide which was subsequently discontinued... she had regained about 10 kg since stopping treatment with semaglutide.
Why this rating
Single case report (n=1), not a systemic study.
Source
Incretin Receptor Agonist, Semaglutide, as a Treatment for Alectinib-Induced Excessive Weight Gain. A Case Report
Alexandria TM Lee et al. · Lung Cancer Targets and Therapy · 2025
DOI 10.2147/lctt.s549011
case_report · n=1Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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