Hormonal
Tirzepatide (10 mg and 15 mg) achieves statistically equivalent total body weight loss to sleeve gastrectomy (SG), with both interventions demonstrating superior efficacy compared to other pharmacotherapies.
If you are an adult with obesity, high-dose Tirzepatide (10-15 mg weekly) can help you lose approximately 21% of your body weight, which is statistically the same amount of weight loss achieved by sleeve gastrectomy surgery. This makes it a highly effective non-surgical option, though it requires weekly injections and lifestyle modifications.
SG (MD 21.1% TWL, 95% CI 14.2% to 28.0%) and Tirzepatide 10 or 15 mg (MD 21.3% TWL, 95% CI 17.3% to 25.2%) demonstrated statistically equivalent weight-loss efficacy (P-score: 0.84)... Tirzepatide 10 mg and 15 mg is equivalent to SG regarding weight-loss efficacy.
Why this rating
Based on a network meta-analysis of 23 RCTs with 14,293 participants, predominantly low risk of bias.
Source
Comparison of pharmacotherapies for obesity with sleeve gastrectomy: a network meta-analysis and systematic review
Zachary Omeh et al. · Expert Review of Endocrinology & Metabolism · 2026
DOI 10.1080/17446651.2026.2656247
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