Research
Hormonal
Prolonged calorie restriction reduces fasting insulin levels and core body temperature in nonobese overweight adults, aligning with biomarkers associated with longevity in rodents and primates.
Calorie restriction lowers fasting insulin and body temperature, which are markers linked to longer life in animals and observational human studies. This suggests that maintaining lower insulin and slightly lower body temperature through moderate calorie restriction may support longevity.
StrongSupportsVERY_HIGH confidence
Our findings suggest that 2 biomarkers of longevity (fasting insulin level and body temperature) are decreased by prolonged calorie restriction in humans...
Why this rating
RCT with blinded assessment and rigorous biochemical analysis.
Source
Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals
Leonie K. Heilbronn et al. · JAMA · 2006
DOI 10.1001/jama.295.13.1539
rct · n=48Cited 977×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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