Hormonal

Improvements in insulin sensitivity (HOMA-IR) and intrahepatic lipid content during caloric restriction are transient and not maintained during the weight maintenance phase, unlike other cardiometabolic markers.

Be aware that while caloric restriction improves insulin sensitivity during the weight loss phase, this specific benefit may not persist once you stop losing weight, even if you maintain the lower calorie intake. Other cardiovascular benefits, like lower blood pressure and better cholesterol, do persist. This suggests that maintaining a healthy weight and diet is crucial, but you might need additional strategies (like exercise or specific dietary components) to sustain insulin sensitivity improvements long-term.