Hormonal
Once-weekly subcutaneous semaglutide 2.4 mg, used as an adjunct to lifestyle interventions, produces substantial and sustained weight loss (mean 14.9% at 68 weeks) and improves cardiometabolic risk factors in adults with overweight or obesity.
If you have obesity or overweight with related health issues, once-weekly semaglutide 2.4 mg combined with a modest calorie deficit and regular exercise can lead to significant, sustained weight loss (around 15% on average) and better heart health markers. Start with the lowest dose to minimize stomach upset, and expect side effects like nausea to fade over time.
In STEP 1, in adults with overweight or obesity without T2D receiving semaglutide (n = 1,306) or placebo (n = 655), once-weekly subcutaneous semaglutide plus lifestyle intervention from baseline to week 68 was associated with substantial, sustained, clinically relevant mean weight loss of 14.9% versus 2.4% for placebo... Semaglutide was also associated with greater improvements compared with placebo in cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated hemoglobin levels, and lipid levels
Why this rating
Based on multiple phase 3, double-blind, randomized, multinational trials (STEP 1-5) involving nearly 5,000 participants.
Source
Efficacy and safety of semaglutide for weight management: evidence from the STEP program
Anastassia Amaro et al. · Postgraduate Medicine · 2022
DOI 10.1080/00325481.2022.2147326
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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