Hormonal
A multi-component intervention (SAMMAS) combining low-carbohydrate nutrition (≤30% carbs), meal replacement, continuous glucose monitoring, and telemedical coaching significantly reduces body weight and fasting insulin in overweight/obese adults compared to a control group, with effects sustained at 52 weeks.
To lose weight and improve metabolic health, consider a structured program that combines a low-carbohydrate diet (limiting carbs to 30% or less of calories), potentially using meal replacement formulas for some meals, and leveraging technology like glucose monitors and coaching for accountability. This approach targets insulin levels to facilitate fat loss, rather than relying solely on calorie counting.
The estimated treatment difference in weight reduction after 12 weeks... showed a pronounced effect in favour of SI (−6.3 kg with (95% confidence interval) (−7.4; −4.5) (p < 0.001))... After 26 and 52 weeks, weight reduction could be maintained in the whole group (both groups together) by −6.7 kg (−9.5; −3.8) (p < 0.001) and −6.1 kg (−9.2; −2.7) (p < 0.01).
Why this rating
Randomized Controlled Trial with intention-to-treat analysis, though sample size is small (n=30) and follow-up is moderate (52 weeks).
Source
Weight Reduction by the Low-Insulin-Method—A Randomized Controlled Trial
Martin Röhling et al. · Nutrients · 2020
DOI 10.3390/nu12103004
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