Research
Hormonal
Long-term adherence to low-carbohydrate diets may attenuate weight loss benefits and potentially increase LDL cholesterol in some individuals, raising cardiovascular risk concerns.
While LCDs work well for short-term weight loss, be aware that benefits may diminish after a year, and some people see their bad cholesterol (LDL) rise. Regular monitoring of lipids and liver health is essential if you stay on this diet long-term.
ModerateQualifiesMEDIUM confidence
Regarding the long-term efficacy of LCDs on patients with type 2 diabetes, the existing evidence has suggested that after 12 months the efficacy of LCDs attenuated... Furthermore, in the long term, in mice, LCDs induced non-alcoholic fatty liver disease and decreased insulin sensitivity...
Why this rating
Based on mixed human data and animal models; long-term human RCTs are scarce.
Source
Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus
Eleni Pavlidou et al. · Metabolites · 2023
DOI 10.3390/metabo13020240
systematic_review · n=1394Cited 19×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
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