Research
Macro partitioning
Polyglucosamine supplementation (800-1700 mg/day) combined with caloric restriction and physical activity produces a statistically significant, albeit modest, reduction in body weight (-1.78 kg) and BMI (-1.52 kg/m2) compared to lifestyle interventions alone in overweight and obese adults.
If you are overweight, taking polyglucosamine (approx 1-1.7g daily, split into doses with meals) alongside a calorie-restricted diet and moderate exercise will help you lose slightly more weight (about 1.8 kg more) than diet and exercise alone over 3-12 months. It is not a magic solution, but a small booster.
ModerateSupportsMEDIUM confidence
The meta-analyzed mean differences for random effects showed that polyglucosamine supplementation improves weight loss by −1.78 kg [−2.78, −0.79], BMI by −1.52 kg/m2 [−3.58, 0.54]...
Why this rating
Meta-analysis of 4 RCTs, but heterogeneity in dosages and protocols exists.
Source
Effect of Polyglucosamine on Weight Loss and Metabolic Parameters in Overweight and Obesity: A Systematic Review and Meta-Analysis
Simone Perna et al. · Nutrients · 2020
DOI 10.3390/nu12082365
Meta-analysis · 4 studiesCited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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