Macro partitioning

Tirzepatide treatment for obesity results in a 3:1 ratio of fat mass reduction to fat-free mass (FFM) reduction, leading to improved body composition rather than proportional lean tissue loss.

If you are using Tirzepatide for weight loss, you can expect your body composition to improve favorably. The medication targets fat stores more aggressively than lean muscle tissue, resulting in roughly three times more fat loss than muscle loss. This helps maintain your metabolic rate and physical function better than traditional caloric restriction alone, which often depletes lean mass proportionally.