Research

Hormonal

Continued treatment with Tirzepatide maintains significant weight loss and cardiometabolic improvements, whereas discontinuation leads to partial weight regain and loss of benefits, demonstrating that long-term adherence is required to sustain outcomes.

If you are using Tirzepatide for weight loss, understand that it is a long-term treatment, not a short-term fix. Stopping the medication will likely cause you to regain most of the weight you lost. To keep the weight off, you must continue the medication indefinitely, combined with healthy lifestyle habits, just as you would manage high blood pressure with medication.

GoodQualifiesHIGH confidence
Those who discontinued tirzepatide regained weight to a mean of 97.0 kg whereas those who continued to take the drug achieved a mean weight of 79.1 kg... the slope appeared to continue to rise and given enough time would probably get back to baseline eventually.
Iskandar Idris · Diabetes Obesity and Metabolism Now · 2023

Why this rating

Based on a Phase 3 randomized controlled trial (SURMOUNT-4) with a large sample size (n=783) and long duration (88 weeks), though presented as an abstract/presentation summary rather than full peer-reviewed text.

Source

Tirzepatide maintained significant weight loss when treatment was continued in a follow‐up study

Iskandar Idris · Diabetes Obesity and Metabolism Now · 2023

DOI 10.1002/doi2.79

narrative_review · n=783
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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