Hormonal
For patients with type 2 diabetes and chronic kidney disease (CKD), SGLT2 inhibitors are recommended to reduce CKD progression, with GLP-1 receptor agonists as an alternative if SGLT2 inhibitors are contraindicated.
If you have diabetes and kidney disease, ask your doctor about SGLT2 inhibitors (like empagliflozin) or GLP-1 agonists (like liraglutide). These drugs have been proven to slow down kidney damage and reduce the risk of needing dialysis, offering benefits beyond just lowering blood sugar.
For patients with type 2 diabetes and CKD, with or without CVD, consider the use of an SGLT2 inhibitor shown to reduce CKD progression or, if contraindicated or not preferred, a GLP-1 receptor agonist shown to reduce CKD progression (Figs. 2 and 3).
Why this rating
Based on CVOTs showing significant reduction in composite renal endpoints (new/worsening nephropathy, doubling of creatinine, ESRD).
Source
Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Melanie J. Davies et al. · Diabetes Care · 2018
DOI 10.2337/dci18-0033
More from this paper
- For patients with type 2 diabetes and established atherosclerotic cardiovascular disease (ASCVD), sodium-glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide 1 (GLP-1) receptor agonists with proven cardiovascular benefit are recommended as part of glycemic management, regardless of baseline HbA1c.Strong
- Diabetes Self-Management Education and Support (DSMES) is a cost-effective intervention that significantly improves clinical and psychological outcomes, glycemic control, and reduces all-cause mortality in type 2 diabetes.Good
Related findings · Hormonal
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