Hormonal
Insulin resistance and impaired insulin secretion are the primary physiological precursors to the development of non-insulin-dependent diabetes mellitus (NIDDM), with insulin resistance preceding hyperinsulinemia and hyperglycemia.
Diabetes risk is driven by how your body handles insulin, not just blood sugar levels. If you have a family history or risk factors, prioritize improving insulin sensitivity through regular physical activity and maintaining a healthy weight, as these factors precede the onset of high blood sugar.
We conclude that insulin resistance and hyperinsulinemia precede the development of NIDDM and that the subsequent development of hyperglycemia is associated with a failure of insulin secretion.
Why this rating
Prospective longitudinal study in a well-defined population (Pima Indians) with rigorous metabolic testing.
Source
Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians
Stephen Lillioja et al. · New England Journal of Medicine · 1993
DOI 10.1056/nejm199312303292703
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →