Research
Macro partitioning
Trans fatty acids significantly increase the risk of coronary heart disease by raising LDL cholesterol, lowering HDL cholesterol, increasing lipoprotein(a), and promoting insulin resistance.
Avoid trans fats completely. They are found in partially hydrogenated oils, often in baked goods, crackers, and fried foods. Eliminating them significantly lowers heart disease risk.
StrongSupportsHIGH confidence
A higher intake of trans fat can contribute to increased risk of CHD through multiple mechanisms. First, trans fatty acids raise LDL cholesterol levels... and lower HDL cholesterol... Second, trans fat increases lipoprotein (a) levels... Fourth, trans fatty acids can adversely affect essential fatty acid metabolism... Finally, recent data have suggested that high intake of trans fat may promote insulin resistance in humans
Why this rating
Consistent findings across prospective cohort studies (Nurses' Health Study, Health Professionals' Follow-up Study) and metabolic studies.
Source
Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
Frank B. Hu et al. · Journal of the American College of Nutrition · 2001
narrative_reviewCited 903×
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