Hormonal
Adult weight gain after age 18 increases the risk of postmenopausal breast cancer incidence and mortality, particularly in women who do not use postmenopausal hormones.
If you are postmenopausal, avoiding significant weight gain after age 18 is one of the most effective ways to lower your risk of breast cancer. This is especially true if you do not use hormone replacement therapy. Focus on maintaining a stable weight through diet and physical activity, as weight gain is a stronger predictor of risk than your current body weight alone.
Adult weight gain, which largely reflects an increase in body fat, may be a better variable to assess adiposity and its metabolic consequences than body weight itself... Weight gain after the age of 18 years was unrelated to breast cancer incidence before menopause, but was positively associated with incidence after menopause.
Why this rating
Large prospective cohort (Nurses' Health Study, n=95,256), long follow-up (16 years), and robust statistical adjustment for confounders.
Source
Dual Effects of Weight and Weight Gain on Breast Cancer Risk
Zhiping Huang et al. · JAMA · 1997
DOI 10.1001/jama.1997.03550170037029
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →