Research

Hormonal

Consumption of high-glycemic index (GI) meals induces rapid glucose absorption, leading to hyperinsulinemia and suppressed glucagon, which lowers circulating metabolic fuels (glucose and fatty acids) and triggers compensatory overeating in obese subjects.

For obese individuals, choosing high-glycemic foods (like instant oatmeal or white bread) over low-glycemic options (like steel-cut oats or legumes) can trigger a hormonal response that lowers blood fuel levels and increases hunger, leading to significantly higher calorie consumption later in the day, even if the initial meal size is the same. Prioritize food structure and glycemic index to manage appetite.

ModerateSupportsMEDIUM confidence
The rapid absorption of glucose after consumption of high-GI meals induces a sequence of hormonal and metabolic changes that promote excessive food intake in obese subjects.
David S. Ludwig et al. · PEDIATRICS · 1999

Why this rating

Small sample size (n=12), short duration (acute study), and lack of blinding limit generalizability, though the physiological mechanism is clearly demonstrated.

Source

High Glycemic Index Foods, Overeating, and Obesity

David S. Ludwig et al. · PEDIATRICS · 1999

DOI 10.1542/peds.103.3.e26

crossover · n=12Cited 706×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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