Research
Hormonal
Switching from Liraglutide to Semaglutide results in significant additional weight loss and FBS reduction, but does not significantly impact HbA1c levels.
If you are currently on Liraglutide and struggling with weight or fasting blood sugar, switching to Semaglutide may help you lose more weight and lower your FBS. However, this switch is unlikely to significantly improve your HbA1c levels.
ModerateQualifiesMEDIUM confidence
Transitions from Liraglutide to Semaglutide did not significantly impact HbA1c levels. However, weight loss (2.48; 95% CI: 0.45–4.51; p = 0.02) and reduced FBS levels (10.76; 95% CI: 0.55–20; p = 0.04) were observed.
Why this rating
Based on 4 studies (2 RCTs, 2 cohorts).
Source
Comparative effectiveness of semaglutide versus liraglutide, dulaglutide or tirzepatide: a systematic review and meta-analysis
Mohammad Amin Karimi et al. · Frontiers in Pharmacology · 2025
DOI 10.3389/fphar.2025.1438318
Meta-analysis · 16 studiesCited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide demonstrates superior efficacy compared to Liraglutide in reducing hemoglobin A1c (HbA1c) levels, though it shows no significant difference in weight loss or fasting blood sugar (FBS) reduction compared to Liraglutide.Good
- Semaglutide demonstrates superior efficacy compared to Dulaglutide in reducing both HbA1c and Fasting Blood Sugar (FBS), but shows no significant difference in weight loss or BMI reduction.Good
- Tirzepatide demonstrates superior efficacy compared to Semaglutide in reducing HbA1c levels, but shows no clear superiority in weight loss or FBS reduction.Moderate
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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