Research
Hormonal
Membrane-bound GPNMB on anti-inflammatory macrophages reduces oxidative stress, lipid accumulation, and fibrosis in the liver by interacting with calnexin on Kupffer and stellate cells.
This finding suggests that maintaining healthy macrophage function in fat tissue may have downstream benefits for liver health, potentially reducing the risk of fatty liver disease associated with obesity.
ModerateSupportsMEDIUM confidence
sGPNMB secreted by adipocytes from obese mice was responsible for decreased oxidative stress, fat deposition, and fibrosis in the liver by interacting with calnexin on Kupffer and stellate cells.
Why this rating
Based on review of murine models and in vitro studies.
Source
Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity
Valentina Bianco et al. · Experimental and Clinical Endocrinology & Diabetes · 2023
DOI 10.1055/a-2192-0101
narrative_reviewCited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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