Hormonal
The risk of cardiovascular disease (myocardial infarction and stroke) is significantly elevated during the prediabetic phase, starting at least 15 years before the clinical diagnosis of type 2 diabetes.
If you have risk factors for diabetes (such as high blood pressure, high cholesterol, or family history), your cardiovascular risk is already elevated, even if you haven't been diagnosed with diabetes yet. Do not wait for a diabetes diagnosis to aggressively manage blood pressure, cholesterol, and lifestyle factors, as the 'clock' for heart disease starts ticking years in advance.
Our data indicate a substantially elevated risk of CVD before clinical diagnosis of type 2 diabetes in women... The risk for CVD began to increase at least 15 years before diabetes diagnosis.
Why this rating
Large prospective cohort (NHS), 20-year follow-up, 117,629 participants, rigorous adjustment for confounders.
Source
Elevated Risk of Cardiovascular Disease Prior to Clinical Diagnosis of Type 2 Diabetes
Frank B. Hu et al. · Diabetes Care · 2002
DOI 10.2337/diacare.25.7.1129
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →