Intensive, multicomponent behavioral weight loss interventions produce statistically significant, albeit modest, weight loss (-2.4 kg) and reduce the incidence of type 2 diabetes in adults with overweight or obesity, without increasing serious adverse events.

Participants who received behavior-based weight loss interventions generally lost more weight and had greater reductions in waist circumference than those in control conditions at up to 24 months followup. Intervention participants had a pooled −2.4 kg (−5.3 lb) (95% CI, −2.8 to −1.9 kg; k=67; N=22065; I2=90.0%) greater weight loss at 12 to 18 months... Participants who received behavior-based weight loss interventions had a decreased probability of developing type 2 diabetes compared with control conditions with an absolute risk reduction of approximately 14.5% in both trials over 3 to 9 years.