Hormonal
GLP-1 receptor agonists reduce hospitalizations for heart failure (HHF) by approximately 10-11%, although their effect on heart failure with reduced ejection fraction (HFrEF) is neutral or potentially harmful in small studies.
If you have Type 2 Diabetes and heart failure, GLP-1 RAs can help reduce the risk of being hospitalized for heart failure. However, if you have a specific type of heart failure where the heart muscle is weak (HFrEF), the data is less clear, and you should discuss the risks and benefits with your doctor.
Two meta-analyses including the 8 CVOTs including 60 080 patients found HHF to be reduced by 10% to 11%. ... In the placebo-controlled LIVE study in 241 patients with HF with reduced ejection fraction with and without diabetes, liraglutide treatment during 24 weeks did not change left ventricular ejection fraction, quality of life, or HF symptoms. However, patients in the liraglutide group exhibited a higher risk for cardiovascular events...
Why this rating
Strong evidence for HHF reduction in large CVOTs; weaker evidence for HFrEF due to small sample sizes and conflicting signals.
Source
GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes
Nikolaus Marx et al. · Circulation · 2022
DOI 10.1161/circulationaha.122.059595
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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