Hormonal
High intake of trans-fatty acids from partially hydrogenated vegetable oils significantly increases the risk of myocardial infarction, independent of plasma cholesterol levels.
To lower your risk of heart attack, minimize your intake of trans-fatty acids, specifically those from partially hydrogenated vegetable oils. Focus on reducing consumption of stick margarine, which is a major source, and limit processed foods like cookies, crackers, and fried foods that often contain these fats. Opt for tub margarine or other unsaturated fats instead, as the study indicates the risk is driven by vegetable-derived trans-isomers rather than animal-derived ones.
These data support the hypothesis that intake of partially hydrogenated vegetable oils may contribute to the risk of myocardial infarction.
Why this rating
Case-control design with strong statistical significance (P<.0001) and adjustment for multiple confounders, though not a randomized trial.
Source
Trans-fatty acids intake and risk of myocardial infarction.
Alberto Ascherio et al. · Circulation · 1994
DOI 10.1161/01.cir.89.1.94
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →