Research
Hormonal
A glucose disposal rate (GDR) below 5.3 mg/kgFFM+17.7 min during an 80 mU/m2·min hyperinsulinemic-euglycemic clamp identifies insulin resistance with 83% sensitivity and 96% specificity.
If your metabolic test uses a lower insulin dose (80 mU/m2·min), a glucose disposal rate below 4.1 mg/kg fat-free mass per minute is a strong indicator of insulin resistance, with very high specificity.
ModerateSupportsMEDIUM confidence
In subjects without diabetes, the mean GDRadj was 8.2 ± 3.0 mg/kgFFM+17.7 z min compared with 3.3 ± 0.7 mg/kgFFM+17.7 z min in subjects with diabetes, and the cutoff for defining insulin resistance was 4.1 mg/kgFFM+17.7 z min with a maximal sensitivity and specificity of 83 and 96%, respectively (aROC = 0.98).
Why this rating
Based on a smaller sub-sample (n=86) of the total cohort, reducing statistical power compared to the primary analysis.
Source
Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps
Charmaine S. Tam et al. · Diabetes Care · 2012
DOI 10.2337/dc11-2339
cross_sectional · n=263Cited 362×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A glucose disposal rate (GDR) below 5.6 mg/kgFFM+17.7 min during a 120 mU/m2·min hyperinsulinemic-euglycemic clamp identifies insulin resistance with 75% sensitivity and 71% specificity in white populations.Good
- Insulin resistance can be accurately predicted using routine clinical variables (HOMA-IR, HDL, fasting insulin) without performing a hyperinsulinemic-euglycemic clamp.Good
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