Research
Hormonal
GIP promotes triglyceride storage in white adipose tissue and may contribute to ectopic fat accumulation (fatty liver) in mice, acting as an obesogenic hormone in this context.
Endogenous GIP promotes fat storage in adipose tissue, particularly with high-sugar/high-fat diets. This 'obesogenic' effect is part of the biological puzzle that dual GIP/GLP-1 drugs must navigate to achieve net weight loss.
GoodSupportsMEDIUM confidence
GIP, but not GLP-1 increases triglyceride storage in white adipose tissue... GIP, therefore, promotes ectopic fat storage in mice, the hallmark of 'unhealthy' obesity, and may similarly mediate the unfavorable effects not only of high fat diets, but also of rapidly absorbed or 'high glycemic index'-carbohydrates
Why this rating
Based on animal studies (mice) cited in the review.
Source
The evolving story of incretins ( <scp>GIP</scp> and <scp>GLP</scp> ‐1) in metabolic and cardiovascular disease: A pathophysiological update
Michael A. Nauck et al. · Diabetes Obesity and Metabolism · 2021
DOI 10.1111/dom.14496
narrative_reviewCited 356×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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