Hormonal
Pioglitazone treatment decreases COL6A3 mRNA expression in obese patients with type 2 diabetes, with the magnitude of decrease proportional to baseline expression levels.
For individuals with type 2 diabetes, the medication pioglitazone has been shown to reduce markers of fat tissue fibrosis (COL6A3). This reduction is most pronounced in those with higher baseline levels. This suggests that pioglitazone may help remodel adipose tissue, potentially reducing inflammation. This is a prescription medication and should be discussed with a healthcare provider.
Pioglitazone decreased COL6A3 mRNA, and the change was inversely proportional to baseline COL6A3 mRNA (r = -0.95, P < 0.0001).
Why this rating
Small sample size (n=14) for the pioglitazone study limits generalizability, but the statistical correlation is very strong.
Source
Adipose Tissue Collagen VI in Obesity
Magdalena Pasarica et al. · The Journal of Clinical Endocrinology & Metabolism · 2009
DOI 10.1210/jc.2009-0947
More from this paper
- Elevated expression of the collagen VI alpha-3 chain (COL6A3) in human adipose tissue is associated with increased visceral adipose tissue mass, reduced adipocyte size, and heightened macrophage infiltration and inflammation.Good
- Acute overfeeding leading to weight gain increases COL6A3 mRNA expression in human adipose tissue.Good
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