Hormonal
A low-glycemic load diet produces greater weight loss and body fat reduction than a low-fat diet specifically in obese young adults with high insulin secretion (high 30-minute post-glucose insulin levels).
If you are obese and struggling with weight loss, your body's insulin response to carbohydrates might dictate which diet works for you. If you have high insulin levels after eating carbs, a low-glycemic load diet (focusing on nonstarchy vegetables, legumes, and temperate fruits) is likely more effective for weight loss than a standard low-fat diet. If your insulin response is normal, both diets may yield similar results. Consider getting your insulin response tested to guide your dietary choice.
For those with insulin concentration at 30 minutes above the median (57.5 µIU/mL; n=28), the low–glycemic load diet produced a greater decrease in weight (–5.8 vs –1.2 kg; P=.004) and body fat percentage (–2.6% vs –0.9%; P=.03) than the low-fat diet at 18 months.
Why this rating
Randomized controlled trial with rigorous blinding of outcome assessors and standardized counseling, though the subgroup analysis relies on a post-hoc stratification of a subset of participants.
Source
Effects of a Low–Glycemic Load vs Low-Fat Diet in Obese Young Adults
Cara B. Ebbeling et al. · JAMA · 2007
DOI 10.1001/jama.297.19.2092
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