Hormonal
DHA is most strongly associated with reduced risk of coronary heart disease (CHD) death, particularly arrhythmic CHD death, while DPA is most strongly associated with stroke death.
If you are concerned about heart rhythm issues, ensuring adequate DHA levels might be particularly important. For stroke prevention, DPA levels also show strong protective associations. This suggests that a balanced intake of all long-chain omega-3s (EPA, DHA, DPA) is beneficial, rather than focusing on just one.
Among CVD subtypes, DHA seemed most strongly related to CHD death (40% lower risk), especially arrhythmic CHD death (45% lower risk), whereas DPA was most strongly related to stroke death (47% lower risk).
Why this rating
Observational cohort study; associations are strong but causal mechanisms for specific fatty acids are inferred.
Source
Plasma Phospholipid Long-Chain ω-3 Fatty Acids and Total and Cause-Specific Mortality in Older Adults
Dariush Mozaffarian et al. · Annals of Internal Medicine · 2013
DOI 10.7326/0003-4819-158-7-201304020-00003
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