Hormonal
Obesity involves the biological defense of an elevated body fat mass set point, driven by homeostatic mechanisms that resist fat loss through increased hunger and metabolic efficiency.
Understand that your body actively fights against fat loss through biological mechanisms like increased hunger and reduced metabolic rate. This is not a failure of willpower but a physiological response. Effective treatment requires strategies that address these biological defenses, not just caloric restriction.
Obesity occurs in genetically susceptible individuals and involves the biological defense of an elevated body fat mass... The adaptive response to fat loss induced by calorie-restricted diets illustrates how coordinate regulation of ARC neurons participates in energy homeostasis... These responses to fat loss appear to be operative in obese as well as lean individuals.
Why this rating
The paper is a comprehensive clinical review citing high-quality evidence and primary references.
Source
Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity
Stephan J. Guyenet et al. · The Journal of Clinical Endocrinology & Metabolism · 2012
DOI 10.1210/jc.2011-2525
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