Hormonal
In humans with Type 2 diabetes, apM1 (adiponectin) mRNA expression is significantly reduced in both omental and subcutaneous adipose tissue compared to lean and obese non-diabetic controls.
This research highlights that low levels of the fat-derived hormone adiponectin (apM1) are a hallmark of Type 2 diabetes, distinct from obesity alone. While not a direct intervention, maintaining healthy adipose tissue function and managing blood glucose are critical for preserving normal adiponectin levels, which may help mitigate insulin resistance.
Using RT-PCR we confirmed that apM1 mRNA levels were significantly reduced in omental adipose tissue of obese patients with Type 2 diabetes compared with lean and obese normoglycemic subjects. Although less pronounced, apM1 mRNA levels were reduced in subcutaneous adipose tissue of Type 2 diabetic patients.
Why this rating
Small sample size (n=4-10 per group), observational design, and reliance on RT-PCR rather than protein quantification.
Source
Decreased Expression Of apM1 in Omental and Subcutaneous Adipose Tissue of HumansWith Type 2 Diabetes
Michael A. Statnick et al. · Journal of Diabetes Research · 2000
DOI 10.1155/edr.2000.81
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