Macro partitioning
Higher circulating levels of linoleic acid (LA), the primary omega-6 polyunsaturated fatty acid, are associated with significantly lower total mortality and cardiovascular disease mortality in older adults, with no evidence of increased risk.
For older adults, maintaining higher levels of linoleic acid (found in vegetable oils like soybean, corn, and sunflower oil) is associated with a lower risk of dying from heart disease or other causes. This benefit appears independent of omega-3 intake, suggesting that consuming recommended amounts of LA-rich oils is safe and potentially beneficial for longevity.
In this prospective cohort study of older US adults, higher circulating LA was associated with lower total mortality... Among causes of mortality, LA demonstrated stronger inverse association with CVD death, in particular non-arrhythmic CHD death and CHF death, with ~50% lower risk across quintiles.
Why this rating
Large prospective cohort study (n=2,792) with long follow-up (18 years) and objective biomarkers, though observational design limits causal inference.
Source
Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality
Jason Wu et al. · Circulation · 2014
DOI 10.1161/circulationaha.114.011590
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →