Hormonal
Sustained caloric restriction (800 kcal/day) followed by weight maintenance significantly reduces low-grade inflammation and improves lipid metabolism biomarkers in overweight/obese individuals.
For overweight individuals, a short period of strict caloric restriction (around 800 kcal/day) can significantly reduce chronic inflammation and improve lipid profiles. Crucially, maintaining the weight loss keeps these biological benefits active, suggesting that the initial 'shock' to the system has long-term metabolic advantages if the weight is kept off.
The weight loss and weight maintenance resulted in sustained effects on low-grade inflammation, as well as steroid hormone and lipid metabolism, indicating beneficial effects.
Why this rating
Large-scale (n=1508 samples), multicenter, randomized controlled trial design with robust proteomic validation.
Source
Analysis of 1508 Plasma Samples by Capillary-Flow Data-Independent Acquisition Profiles Proteomics of Weight Loss and Maintenance
Roland Bruderer et al. · Molecular & Cellular Proteomics · 2019
DOI 10.1074/mcp.ra118.001288
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