Hormonal
Obese individuals with type 2 diabetes exhibit significantly lower expression of key adipogenic genes (SREBP1c, STAT5A, PPARγ2) in subcutaneous adipose tissue compared to obese non-diabetic individuals, which is associated with larger fat cell size and reduced insulin sensitivity.
For obese individuals with type 2 diabetes, the body's ability to create new fat cells (adipogenesis) is impaired compared to obese individuals without diabetes. This leads to existing fat cells becoming larger (hypertrophy), which is strongly linked to insulin resistance. The focus should be on improving metabolic health and insulin sensitivity, as this may support healthier fat storage dynamics.
Three genes (SREBP1c, p < 0.01; STAT5A, p < 0.02; and PPARγ2, p < 0.02) had significantly lower expression in obese type 2 diabetics... As expected, subjects with type 2 diabetes had lower glucose disposal... and larger fat cells... as compared with obese control subjects.
Why this rating
Cross-sectional study with matched controls and rigorous metabolic testing (clamps), but lacks causal proof of intervention.
Source
Decreased Expression of Adipogenic Genes in Obese Subjects with Type 2 Diabetes
Séverine Dubois et al. · Obesity · 2006
DOI 10.1038/oby.2006.178
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