Hormonal
Plasma ghrelin concentrations increase significantly during negative energy balance (weight loss) and decrease during overfeeding, indicating that ghrelin acts as a homeostatic signal to defend body weight rather than simply reflecting current energy intake.
Your body uses ghrelin to signal hunger when you are in a calorie deficit and satiety when you are overfed. This is a natural defense mechanism to maintain body weight. Understanding this can help you anticipate hunger cues during weight loss and recognize that these changes are physiological, not a failure of willpower.
Plasma ghrelin concentrations increased significantly during the negative energy balance period and decreased significantly during the overfeeding period.
Why this rating
Study uses a rigorous design with twins, controlled environments, and direct measurement of hormonal changes in response to specific energy balance interventions.
Source
Plasma Ghrelin Concentration and Energy Balance: Overfeeding and Negative Energy Balance Studies in Twins
Éric Ravussin et al. · The Journal of Clinical Endocrinology & Metabolism · 2001
DOI 10.1210/jcem.86.9.8003
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