Hormonal
Long-term testosterone replacement therapy in hypogonadal men produces substantial, sustained, and progressive weight loss, waist circumference reduction, and BMI decline.
If you are a hypogonadal man with low testosterone, testosterone replacement therapy (specifically testosterone undecanoate) can lead to significant and sustained weight loss, waist reduction, and improved BMI over several years. This effect is observed even without intentional lifestyle changes, suggesting that correcting hormonal deficits is a primary driver of body composition in this population. Consult a healthcare provider to determine if you are a candidate for this therapy.
In an uncontrolled, observational cohort, normalizing serum T to normal physiological levels produced consistent loss of BW, WC, and BMI. These improvements were progressive over the full 5 years of the study.
Why this rating
The study is a single-center, open-label, uncontrolled registry, which introduces potential bias and limits causal inference compared to RCTs.
Source
Long‐term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss
Farid Saad et al. · Obesity · 2013
DOI 10.1002/oby.20407
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