Mixed
Long-term weight gain (increasing BMI trajectory) in healthy adults significantly increases the risk of incident chronic kidney disease (CKD), with the effect being strongest in overweight and obese individuals.
If you are gaining weight, even if you are currently healthy and have no diagnosed conditions, you are increasing your risk of developing chronic kidney disease. This risk is driven by worsening blood pressure, insulin resistance, and inflammation, as well as increased body fat. Maintaining a stable weight is crucial for kidney health, especially if you are overweight or obese.
In the multivariable-adjusted Cox proportional hazards model, the increasing BMI trajectory was associated with a 1.4-fold [hazard ratio (HR), 1.41; 95% CI, 1.06–1.87] a higher risk of incident CKD compared with stable BMI trajectory. This association was stronger for overweight and obese individuals. The HRs for CKD development in these two groups were 1.6 (95% CI, 1.06–1.87) and 2.2 (95% CI, 1.40–3.48), respectively.
Why this rating
Large prospective cohort (n=5,393), long follow-up (median 11.5 years), rigorous exclusion of comorbidities, but observational design limits causal inference.
Source
Increased Risk of Chronic Kidney Disease Associated With Weight Gain in Healthy Adults: Insight From Metabolic Profiles and Body Composition
Hae‐Ryong Yun et al. · Frontiers in Medicine · 2021
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