Research
Hormonal
Genetic variants associated with fasting glucose (FG) levels do not show a significant independent association with coronary artery disease risk in this Mendelian randomization analysis.
While fasting glucose is a standard test, this genetic study suggests it may not be the primary driver of heart disease risk compared to overall diabetes status or HbA1c. However, maintaining healthy glucose levels is still important.
ModerateRefutesLOW confidence
this effect was non-significant among 30 genetic variants associated with FG per mmol/L (OR: 1.18, 95% CI: 0.97–1.42; P ¼ 0.102).
Why this rating
Non-significant result, but the study notes limited power to detect an effect for FG.
Source
Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease
Stephanie Ross et al. · European Heart Journal · 2015
DOI 10.1093/eurheartj/ehv083
Meta-analysisCited 137×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Mendelian randomization analysis confirms a causal relationship between diabetes and an increased risk of coronary artery disease, independent of other risk factors like lipids and BMI.Good
- Genetic variants associated with HbA1c levels are linked to an increased risk of coronary artery disease, although this association is attenuated when adjusting for other cardiovascular risk factors.Moderate
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