Macro partitioning
During refeeding after semistarvation, elevated de novo lipogenesis (DNL) combined with increased fat intake causes a rapid overshoot of body fat mass, which takes more than one year to return to baseline levels even with original diet and activity.
After a period of significant weight loss or starvation, your body will likely store fat rapidly when you start eating normally again. This is driven by increased fat synthesis (DNL) and high fat intake. Don't panic; this overshoot is not permanent. If you return to your pre-starvation diet and activity levels, your body fat will eventually return to baseline, but expect it to take over a year, not weeks.
Refeeding caused an elevation of de novo lipogenesis that, along with increased fat intake, resulted in a rapid repletion and overshoot of body fat... body fat mass was predicted to take more than one additional year to return to within 5% of its original value.
Why this rating
The model is validated against the Minnesota Starvation Experiment and an independent short-term caloric restriction study, providing strong mechanistic support.
Source
Computational model of in vivo human energy metabolism during semistarvation and refeeding
Kevin D. Hall · American Journal of Physiology-Endocrinology and Metabolism · 2006
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