Hormonal
Discontinuation of second-generation anti-obesity medications (semaglutide and tirzepatide) leads to rapid and substantial weight regain, often returning to baseline cardiometabolic status, demonstrating the chronic nature of obesity and the need for indefinite treatment.
If you stop taking semaglutide or tirzepatide, you will likely regain most of the weight you lost within a year. This demonstrates that obesity is a chronic condition requiring long-term treatment, similar to high blood pressure. To maintain weight loss, you likely need to continue the medication indefinitely.
Individuals regain weight quickly after discontinuing semaglutide. A subset of 228 STEP-1 participants, who lost a mean 17.3% of baseline weight at week 68, regained an average of two-thirds of their loss (11.6 percentage points) 1 year after discontinuing medication... These results mirror those from STEP 4... confirm the chronicity of obesity and the clear need for its long-term (indefinite) treatment, as with other chronic diseases.
Why this rating
Based on phase 3 trials (STEP 1, STEP 4) with clear follow-up data on weight regain after discontinuation.
Source
The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities
Thomas A. Wadden et al. · Current Obesity Reports · 2023
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