Macro partitioning
An isocaloric ketogenic diet (5% carbohydrate, 80% fat) increases fasting inflammatory markers (CRP, adiponectin) and cholesterol (total, LDL, HDL) compared to a baseline diet (50% carbohydrate, 35% fat) in men with overweight or class I obesity.
If you switch to a strict ketogenic diet (80% fat, 5% carbs) while keeping your calories the same, expect your cholesterol (including LDL and HDL) and inflammatory marker (CRP) levels to rise compared to a standard diet. This effect was observed in men with overweight or obesity over 4 weeks. Monitor your lipids and inflammation if you adopt this diet.
Fasting ketones, glycerol, free fatty acids, glucagon, adiponectin, gastric inhibitory peptide, total and low-density lipoprotein cholesterol, and C-reactive protein were significantly increased on the KD.
Why this rating
Controlled inpatient feeding study with objective biochemical measures, though limited to a small sample (n=17) of men.
Source
Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet
Michael Rosenbaum et al. · Obesity · 2019
DOI 10.1002/oby.22468
More from this paper
- An isocaloric ketogenic diet decreases insulin-mediated antilipolysis (the ability of insulin to suppress fat breakdown) compared to a baseline diet, regardless of the meal consumed.Good
- An isocaloric ketogenic diet significantly lowers fasting triglycerides but raises fasting total, HDL, and LDL cholesterol compared to a baseline diet in men with overweight or obesity.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →