Macro partitioning
An isocaloric ketogenic diet (5% carbohydrate, 80% fat) increases fasting inflammatory markers (CRP, adiponectin) and cholesterol (total, LDL, HDL) compared to a baseline diet (50% carbohydrate, 35% fat) in men with overweight or class I obesity.
If you switch to a strict ketogenic diet (80% fat, 5% carbs) while keeping your calories the same, expect your cholesterol (including LDL and HDL) and inflammatory marker (CRP) levels to rise compared to a standard diet. This effect was observed in men with overweight or obesity over 4 weeks. Monitor your lipids and inflammation if you adopt this diet.
Fasting ketones, glycerol, free fatty acids, glucagon, adiponectin, gastric inhibitory peptide, total and low-density lipoprotein cholesterol, and C-reactive protein were significantly increased on the KD.
Why this rating
Controlled inpatient feeding study with objective biochemical measures, though limited to a small sample (n=17) of men.
Source
Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet
Michael Rosenbaum et al. · Obesity · 2019
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