Research
Macro partitioning
Adequate dietary protein intake (60-75 g/day or up to 1.5 g/kg body weight/day) is critical during AOM therapy to preserve lean body mass and prevent complications like weakness and edema, especially in older adults.
To keep your muscles while losing weight, aim for 60-75 grams of protein daily, or up to 1.5 grams per kilogram of your body weight. Eat high-protein foods first at each meal. This is especially important if you are older to prevent falls and muscle loss.
GoodSupportsHIGH confidence
In patients with obesity, however, protein intakes of at least 60 to 75 g/day and up to 1.5 g/kg body weight/day have been recommended during weight reduction with various treatments... Higher protein intake (i.e., >1.5 g/kg body weight/day) may be considered for select individuals such as those who have undergone a malabsorptive bariatric procedure... older individuals may be at higher risk of excessive muscle loss and risk of falls and fracture with weight loss.
Why this rating
Based on general obesity guidelines and bariatric surgery evidence applied to AOM context.
Source
Nutritional considerations with antiobesity medications
Jaime P. Almandoz et al. · Obesity · 2024
DOI 10.1002/oby.24067
narrative_reviewCited 104×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Antiobesity medications (AOMs) such as semaglutide and tirzepatide significantly reduce energy intake and appetite, necessitating a shift in nutritional focus from caloric restriction alone to ensuring nutrient density and adequate protein intake to prevent lean mass loss and deficiencies.Good
- AOM therapy requires monitoring and potential dose reduction of concomitant medications for diabetes and hypertension due to rapid weight loss and improved metabolic parameters.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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