Research
Hormonal
Sulfonylureas are associated with weight gain, hypoglycemia, and declining long-term efficacy, making them unsuitable as first- or second-line treatments.
Avoid sulfonylureas if possible. They cause weight gain and low blood sugar, and their effectiveness fades over time. Use them only if other, safer options are not available or affordable.
GoodRefutesHIGH confidence
Because novel glucose-lowering agents are available, because sulfonylureas carry the risk of hypoglycemia and weight gain, and because the effects of sulfonylureas decline over the long term, sulfonylureas should not be considered as first- or second line.
Why this rating
Supported by expert consensus panels and clinical trials showing risks.
Source
Drug Therapies for Diabetes
Roni Weinberg Sibony et al. · International Journal of Molecular Sciences · 2023
DOI 10.3390/ijms242417147
narrative_reviewCited 97×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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