Hormonal
Resistance exercise decreases the phosphorylation of eIF2Bε, a mechanism that potentiates the feeding-induced stimulation of p70S6K1 and rpS6, thereby enhancing muscle protein synthesis signaling in young men.
To maximize muscle growth, you must combine resistance training with adequate nutrition. This study shows that exercise changes how your muscles respond to food by deactivating inhibitory signals (eIF2Bε phosphorylation). Without the exercise stimulus, feeding alone does not trigger the same level of anabolic signaling (p70S6K1 and rpS6) as the combination of both.
We conclude that resistance exercise potentiates the effect of feeding on the phosphorylation and presumably activation of critical proteins involved in the regulation of muscle protein synthesis in young men.
Why this rating
Randomized crossover design with human subjects, though small sample size (n=9) limits generalizability.
Source
Resistance exercise decreases eIF2Bε phosphorylation and potentiates the feeding-induced stimulation of p70<sup>S6K1</sup> and rpS6 in young men
Elisa I. Glover et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2008
DOI 10.1152/ajpregu.00097.2008
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