Hormonal
Post-obese individuals who have successfully lost weight exhibit significantly lower plasma leptin concentrations and lower rates of fat oxidation (higher respiratory quotient) compared to never-obese controls matched for body mass index and body fat percentage.
If you have lost weight and maintained it, your body may still be biologically primed to regain it through lower fat burning and lower leptin levels, even if you look healthy. This is a common biological adaptation, not a failure. To counter this, focus on strategies that increase fat oxidation, such as regular exercise and potentially adjusting fat intake, as suggested by the authors.
post-obese subjects had, compared with controls, similar levels of physical activity... and similar RMR... but higher RQ... Leptin concentration correlated positively with percent body fat... and, after adjusting for fat mass and fat-free mass, was lower in post-obese than in control subjects
Why this rating
Small sample size (n=16) and cross-sectional design limit generalizability, though the controlled conditions (weight stability, standardized diet) strengthen internal validity.
Source
Low Plasma Leptin Concentration and Low Rates of Fat Oxidation in Weight‐Stable Post‐Obese Subjects
Claudia Filozof et al. · Obesity Research · 2000
DOI 10.1038/oby.2000.23
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