Hormonal
Discontinuation of GLP-1 therapy leads to significant weight regain (up to two-thirds of lost weight within 1 year), highlighting the necessity of long-term lifestyle interventions and potentially long-term medication use.
Understand that GLP-1 therapy is likely a long-term treatment for obesity. If you stop the medication, you will likely regain a significant portion of your lost weight. Work with your provider to determine if you should stay on the medication long-term or transition to a maintenance strategy that includes intensive lifestyle support.
When GLP-1s are discontinued, weight regain is common—with up to two-thirds of the lost weight regained within 1 years [18–20]. Notably, this has been observed even with accompanying use of conventional nutritional counseling and/or behavioral therapy [18, 19].
Why this rating
Based on multiple observational studies and clinical trials showing consistent weight regain patterns upon discontinuation.
Source
Nutritional priorities to support <scp>GLP</scp>‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society
Dariush Mozaffarian et al. · Obesity · 2025
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